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  • Title: Stereoselective synthesis and in vitro antifungal evaluation of (E)- and (Z)-imidazolylchromanone oxime ethers.
    Author: Emami S, Falahati M, Banifatemi A, Moshiri K, Shafiee A.
    Journal: Arch Pharm (Weinheim); 2002 Jul; 335(7):318-24. PubMed ID: 12207281.
    Abstract:
    A series of (E)- and (Z)-2, 3-dihydro-3-(1H-imidazol-1-yl)-4H-1-benzopyran-4-one oxime ethers have been synthesized and tested for antifungal activity. Most compounds showed moderate to potent in vitro antifungal activity. Among the tested compounds, compound (E)-3d was the most active agent against Candida albicans and Aspergillus niger, and compounds (Z)-(3a) and (E)-3a were the most potent compounds against Microsporum gypseum. Detailed stereoselective synthesis, spectroscopic, and biological data are reported.
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