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  • Title: Norepinephrine transporter and alpha(2c) adrenoceptor allelic variants and personality factors.
    Author: Tsai SJ, Wang YC, Hong CJ.
    Journal: Am J Med Genet; 2002 Aug 08; 114(6):649-51. PubMed ID: 12210281.
    Abstract:
    It has been suggested that reward dependence, as measured by the Tridimensional Personality Questionnaire (TPQ), is related to central noradrenergic activity, a proposition supported by two studies of urinary norepinephrine metabolite. In the current investigation, 190 normal young Han Chinese were examined, with genetic polymorphisms determined for the norepinephrine transporter (1287G/A) and the alpha(2c)-adrenoceptor (Del322-325) to test the association with TPQ personality traits. No significant association was demonstrated for these two polymorphisms and any of the TPQ personality-factor scores, including reward dependence and its subscales. Our negative findings suggest that the investigated polymorphisms of the norepinephrine transporter and the alpha(2c) adrenoceptor do not play a major role in the reward-dependence personality trait as assessed by TPQ.
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