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  • Title: Propriospinal transmission of part of the corticospinal excitation in humans.
    Author: Pierrot-Deseilligny E.
    Journal: Muscle Nerve; 2002 Aug; 26(2):155-72. PubMed ID: 12210379.
    Abstract:
    In humans a substantial part of corticospinal excitation to upper limb motoneurons is mediated through cervical premotoneurons located rostral to motoneurons, analogous to the feline system of C3-C4 propriospinal neurons. The indirect (disynaptic) component of the corticospinal command passing through the propriospinal relay may be updated by the extensive convergence at this level of afferent inputs (both excitatory and inhibitory) from the moving limb. Propriospinal neurons are potently inhibited by feedback inhibitory interneurons facilitated from the motor cortex, and this explains why artificial volleys delivered to the pyramidal system by itself have failed to demonstrate this indirect corticospinal projection. The strength of this indirect corticospinal projection may be estimated in routine practice by the amount of suppression elicited by a cutaneous volley on the ongoing electromyogram of extensor carpi radialis, and is increased in patients recovering from hemiplegia and in early Parkinson's disease.
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