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  • Title: Crow-Fukase syndrome associated with high-output heart failure.
    Author: Araki T, Konno T, Soma R, Nakashima A, Takimoto H, Tofuku Y, Shimizu M.
    Journal: Intern Med; 2002 Aug; 41(8):638-41. PubMed ID: 12211533.
    Abstract:
    A 64-year-old woman was admitted with systemic edema and exertional dyspnea. High-output heart failure was diagnosed by right heart catheterization and she was treated with diuretics. After 3 weeks, her symptoms disappeared but a high cardiac output state persisted. A diagnosis of Crow-Fukase syndrome was made based on the presence of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes. Her serum vascular endothelial growth factor (VEGF) level was markedly elevated after recovery from heart failure. We suspect that an elevated VEGF level and a high cardiac output state may play a role in the pathogenesis of heart failure in Crow-Fukase syndrome.
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