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  • Title: Do fibrinolytic proteins of human bile derive exclusively from gall bladder?
    Author: Gil D, Michalski A, Kondera-Anasz Z, Gil B, Starzewski J, Gonciarz Z.
    Journal: Med Sci Monit; 2001 May; 7 Suppl 1():262-3. PubMed ID: 12211732.
    Abstract:
    BACKGROUND: In this study we addressed the issue of whether fibrinolytic proteins are presented in gall bladder bile only or in choledochus bile as well. MATERIAL AND METHODS: Gall bladder bile was obtained from 20 patients (Group I) undergoing laparoscopic cholecystectomy. Bile from common bile duct was aspirated after insertion Kehr drainage from 9 patients (Group II). The concentrations of t-PA, u-PA, PAI-1 and PAI-2 were measured by ELISA. RESULTS: We have shown that in cholecystectomized patients fibrinolytic proteins can be detected in bile both from gall bladder and from choledochus. Mean concentrations of t-PA, u-PA, PAI-1 were lower in Group II (5.69 ng/ml vs 15.7; 0.46 ng/ml vs 0.7; 16.82 ng/ml vs 26.16 ng/ml) or nearly equal for PAI-2 (343.53 ng/ml vs 341.02). All differences were insignificant (p > 0.05). CONCLUSIONS: Based on these results we concluded that the entire biliary tree produces the fibrinolytic proteins thus this production is not restricted to the gall bladder as it was earlier reported [1].
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