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  • Title: [Effect of sodium ferulate on proliferation of rabbit aortic smooth muscle cells induced by oxidized LDL].
    Author: Yu H, Hong J, Wu D.
    Journal: Zhongguo Zhong Yao Za Zhi; 1999 Jun; 24(6):365-6, 384. PubMed ID: 12212033.
    Abstract:
    OBJECTIVE: To investigate the effect of sodium ferulate on the proliferation and lipid peroxidation of aortic smooth muscle cells(SMC). METHOD: Using experimental models of proliferation of cultured rabbit aortic SMC induced by oxidized-low density lipoprotein, the level of lipoperoxide(LPO) was determined by thiobarbituric acid reactive substance(TBARS) method and 3H-thymidine(3H-TdR) incorporation was used to observe DNA synthesis. RESULTS: SF markedly reduced the increase of medium LPO and inhibited the 3H-TdR incorporation in a dose-dependent manner. CONCLUSION: SF can inhibit the proliferation of SMC. The inhibitory effect may be related to the inhibition of lipid peroxidation.
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