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  • Title: [Pathological morphology of arterioles and main visceal organs in primary hypertension--an analysis of 45 autopsies].
    Author: Chen D, Ren A, Hang Z.
    Journal: Hua Xi Yi Ke Da Xue Xue Bao; 1999 Jun; 30(2):188-91. PubMed ID: 12212056.
    Abstract:
    The autopsy materials of 45 cases of primary hypertension were studied retrospectively. The arteriolar lesions were reviewed. The arterioles < 100 microns in diameter were defined as distal arterioles; those > or = 100 microns and < 300 microns in diameter were proximal arterioles. The lesions of arteriolar wall were categorized as plasma infiltration and hyaline degeneration, and according to seriousness, the latter was divided into three degrees: I, II and III. The results revealed that (1) the arteriolar lesions in different areas of the body were at different stages of seriousness; (2) the changes in the distal arterioles were earlier than those in the proximal ones; in brain, the proximal arterioles dilated first, and then occurred the hyline degeneration; (3) hyaline degeneration took place early in the abdominal organs such as kidney, liver and pancreas, but relatively late in brain; (4) different parts of an organ were at different stages of seriousness; and (5) the lesions in different organs led to different consequences. The pathogenesis of arteriolar sclerosis in primary hypertension was also discussed.
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