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  • Title: [The effects of jiexinkang on the apoptosis of leukemic cells].
    Author: Cao ZH, Xie ZX, Tan DR, Qin Q.
    Journal: Hunan Yi Ke Da Xue Xue Bao; 2000 Oct 28; 25(5):480-2. PubMed ID: 12212126.
    Abstract:
    UNLABELLED: The effects of Chinese medicine jiexinkang(JXK) on apoptosis of leukemic cells were studied by morphology approach and electrophoresis of DNA fragments. RESULTS: 1. The apoptotic cells and apoptotic bodies were found by electrical microscopy and the typical ladders of DNA fragments were detected by electrophoresis. 2. JXK induced apoptosis of leukemic cells(HL-60 and K562) in a certain range of concentration and at appropriate time. The time to K562 cell apoptosis was longer than that of HL-60 and its dosage was larger than that of HL-60. CONCLUSION: HL-60 and K562 leukemic cell apoptosis may be induced by JXK and there is correlation between dose and time. The study provides experimental evidences for the clinical treatment of leukemia.
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