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  • Title: [Effect of puerarin on heart function and serum oxidized-LDL in the patients with chronic cardiac failure].
    Author: Duan S, Li YF, Luo XL.
    Journal: Hunan Yi Ke Da Xue Xue Bao; 2000 Apr 28; 25(2):176-8. PubMed ID: 12212215.
    Abstract:
    OBJECTIVE: To observe the effect of puerarin on heart function and serum oxidized-LDL(ox-LDL) in patients with chronic cardiac failure. METHODS: Seventy-eight patients with chronic cardiac failure were randomly divided into two groups, regular group (R) and regular + puerarin group (P). All patients in two groups received conventional treatment with inotropic agents, diuretic, and vasodilator, etc. The patients in the P group took puerarin 400 mg.d-1 for 10 days. RESULTS: After treatment, the clinical heart function of the patients in the two groups was improved, but there was no significant difference between them; the left ventricular ejection fraction (EF) of patients in the P group was higher than that in the R group(P < 0.05); and serum ox-LDL level was significantly decreased in the P group patients, but that was no change in the R group patients(P < 0.05). CONCLUSION: Puerarin may improve the clinical heart function, increase the left ventricular ejection, meanwhile, it may decrease the level of ox-LDL.
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