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  • Title: [Effect of propofol and midazolam on cerebral oxygen supply and demand imbalance during cardiopulmonary bypass].
    Author: Chen AW, Li L, Chang YT.
    Journal: Hunan Yi Ke Da Xue Xue Bao; 2000 Feb 28; 25(1):65-7. PubMed ID: 12212254.
    Abstract:
    Thirty patients undergoing heart valve replacement were divided randomly into three groups (n = 10): control group, propofol group and midazolam group. Jugular bulb blood oxygen saturation (SjO2), arterialvenous oxygen content difference (Da-vO2) and cerebral oxygen extraction rate(CEO2) were measured at various periods of cardiopulmonary bypass (CPB). The results showed: SjO2 decreased significantly, Da-vO2 and CEO2 increased markedly during rewarming period in control group; but in propofol group and midazolam group, SjO2, CEO2 and Da-vO2 did not decline significantly compared with baseline. It is suggested that administering propofol or midazolam is helpful in avoiding cerebral oxygen supply and demand imbalance during CPB.
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