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  • Title: Modulation of axonal regeneration in neurodegenerative disease: focus on Nogo.
    Author: Strittmatter SM.
    Journal: J Mol Neurosci; 2002; 19(1-2):117-21. PubMed ID: 12212768.
    Abstract:
    Recent work has demonstrated that axonal regeneration in the central nervous system is limited by myelin-derived Nogo binding to an axonal Nogo Receptor. The Nogo system appears to have a physiologic role in regulating structural plasticity. The possibility that the Nogo system contributes to pathologic and compensatory plasticity in Alzheimer's Disease is considered.
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