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  • Title: Effects of tibolone on plasma levels of nitric oxide in postmenopausal women.
    Author: Cicinelli E, Ignarro LJ, Galantino P, Pinto V, Barba B, Schonauer S.
    Journal: Fertil Steril; 2002 Sep; 78(3):464-8. PubMed ID: 12215318.
    Abstract:
    OBJECTIVE: To determine the effects of tibolone on nitric oxide (NO) plasma levels in postmenopausal women. DESIGN: Randomized, double-blind, placebo-controlled, cross-over trial. SETTING: Healthy volunteers in an academic research environment. PATIENT(S): Eighteen healthy women who have been in postmenopause for 1-4 years. INTERVENTION(S): Women received either tibolone 2.5 mg/day (group A) or placebo (group B) for 1 month; then the treatment was inverted for the second month. MAIN OUTCOME MEASURE(S): Plasma concentration of NO stable oxidation products and blood pressure were evaluated at baseline, month 1, and month 2. RESULT(S): Baseline concentration of NO metabolites were similar in both groups. At month 1, mean concentration of NO metabolites increased significantly in group A alone. At the end of month 2, NO metabolite levels in group A returned to baseline, whereas in group B they increased significantly. CONCLUSION(S): Tibolone induced a sustained increase in plasma levels of NO in postmenopausal women, suggesting that tibolone may exert a direct cardiovascular protective effect in postmenopausal women.
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