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  • Title: Is isoniazid ototoxic in patients undergoing hemodialysis?
    Author: Altíparmak MR, Pamuk ON, Pamuk GE, Ataman R, Serdengeçti K.
    Journal: Nephron; 2002 Oct; 92(2):478-80. PubMed ID: 12218336.
    Abstract:
    Drug-induced ototoxicity might sometimes be a problem in end-stage renal failure (ESRF) patients. However, ototoxicity secondary to isoniazid intake has not been reported in ESRF until now. During the last decade, ototoxicity was diagnosed in 16.6% (7/42) of our ESRF patients undergoing hemodialysis (HD) who also used antituberculosis therapy. Streptomycin was not included in any of these regimens, isoniazid was used by all 7 patients with ototoxicity and there was reversal of hearing loss in 2 of these patients after discontinuation of isoniazid. In our ESRF-HD patients who developed ototoxicity during the course of antituberculosis therapy, isoniazid was probably the responsible agent either alone or it added to the side effects of other drugs.
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