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  • Title: Effects of hypophysectomy on plastocyst survival, progesterone secretion and nidation in the spotted skunk.
    Author: Mead RA.
    Journal: Biol Reprod; 1975 May; 12(4):526-33. PubMed ID: 1222177.
    Abstract:
    12 female skunks were hypophysectomized during the 7-month preimplantation period. Sham operations were performed on 7 skunks by drilling through the basisphenoid but without exposing the pituitary. 22 skunks remained as controls. Complete hypophysectomy significantly reduced peripheral plasma progesterone levels within 40 days while there was a tendency for values to increase in sham hypophysectomized skunks. The only obvious effect hypophysectomy had on ovarian histology during the preimplantation period was the abolition of all antral follicles; corpora lutea remained unchanged for up to 90 days. Blastocysts from hypophysectomized skunks were undergoing a slow attrition of cells after Day 34, and there was some indication that hypophysectomy may have a deleterious effect as early as Day 22. Hypophysectomy significantly prolonged the preimplantation period in 6 out of 7 skunks. It was concluded that the pituitary is essential for initiation of nidation.
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