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  • Title: [Influence of methochlopramide on the motor function of the esophagus and the cardial sphincter].
    Author: Krasil'shchikov KB, Groĭsman SD.
    Journal: Biull Eksp Biol Med; 1975 Sep; 80(9):53-6. PubMed ID: 1222276.
    Abstract:
    In acute experiments on cats and in chronic experiments on dogs the contractile activity of the esophagus and the cardiac sphincter was recorded with a ballon pulled from the stomach to the esophagus connected to a catheter. The intravenous injection of Metoclopramide in doses of 0.5--0.6 mg/kg to cats and subcutaneous injection of Metoclopramide in doses of 0.1--0.15 mg/kg to dogs elevated the pressure in the cardiac sphincter significantly increased the motility of the distal esophagus and stimulated the esophago-gastric inhibitory reflex. These effects persisted for 2.5--3 hrs; they were phasic in nature and were preserved after vagotomy in dogs. A conclusion was drawn that Metoclopramide could be useful in pathology of the distal esophagus, including the cardiac sphincter.
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