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  • Title: [Appearance of foci of hematopoiesis and hematopoietic stem cells in the liver of mice following a single administration of cyclophosphane].
    Author: Barkhotkina MF, Repina FB, Svet-Moldavskaia IA.
    Journal: Biull Eksp Biol Med; 1975 Sep; 80(9):89-93. PubMed ID: 1222281.
    Abstract:
    The nidi of hemopoiesis appeared in the liver and the lymph nodes of DBA/2, C57BL/6j and F1 (C57BL/6j X CBA) strains of mice of the 6th day after a single intraperitoneal injection of cyclophosphamide in a dose of 200 mg/kg. This process was accompanied by the appearance of stem hemopoietic cells in the liver. Their maximum number was observed on the 6th and the 9th days. On the 12th day their level decreased, but it still exceeded the one in the animals which received a suspension of normal liver cells. In myelosan exhaustion the pool of the bone marrow and splenic stem cells, the subsequent cyclophosphamide injection failed to induce the appearance of the nidi of hemopoiesis and stem cells in the liver.
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