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  • Title: [Development of pre-hepatic portal hypertension of the rat].
    Author: Aller Reyero MA, Diéguez Fernández B, Nava Hidalgo MP, Cuesta Alvaro P, Sánchez García M, Duran Giménez-Rico HJ, Llamas Matías MA, Arias Pérez J.
    Journal: An Med Interna; 2002 Jul; 19(7):341-51. PubMed ID: 12224142.
    Abstract:
    OBJECTIVE: A long-term study of the prehepatic portal hypertension model by triple stenosing ligation of the portal vein in the rat. METHOD: A cluster analysis of the animals in the different evolutive stages of portal hypertension (1 1/2, 6, 12 and 14 months) has been carried out. This analysis has made it possible to identify three homogeneous groups (A, B and C) in relationship to the liver weight. RESULTS: The animals with liver atrophy (group C) show a decrease of body, splenic and testicular weights as well as a higher development of the portosystemic collateral circulation in relation to the A and B groups. CONCLUSION: The percentage of animals belonging to the group C decrease progressively during the evolution of portal hypertension and those animals corresponding to the group A, in which is superior the liver weight, increase, while the B group does not change.
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