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  • Title: The interplay of dendritic cell subsets in systemic lupus erythematosus.
    Author: Palucka AK, Banchereau J, Blanco P, Pascual V.
    Journal: Immunol Cell Biol; 2002 Oct; 80(5):484-8. PubMed ID: 12225385.
    Abstract:
    Dendritic cells (DC) control immunity and tolerance. Hence, we surmised that systemic lupus erythematosus (SLE), a systemic autoimmune disease with autoreactive T and B cells, might be due to DC alterations. Based on our findings, we are proposing a model of SLE where autoimmune responses are driven by unabated activation of myeloid DC through IFN-alpha produced by plasmacytoid DC. Thus, interplay between DC subsets might represent a key component of SLE pathogenesis.
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