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  • Title: The objective and timing of drug disposition studies, appendix IV. Phenylbutazone formulations: in vitro dissolution and in vivo performance.
    Author: Leeson LJ, Shinal EC, Lukas G, Zak SB, Weiner M.
    Journal: Drug Metab Rev; 1975; 4(2):277-84. PubMed ID: 1222684.
    Abstract:
    Human plasma level studies were conducted on various phenylbutazone formulations. The resultant data indicated that the nature of the formulation had a marked influence on the rate of phenylbutazone absorption. An in vitro dissolution rate apparatus was employed in an attempt to predict potential absorption of phenylbutazone from a given formulation. Based upon the in vitro-in vivo correlation, a new phenylbutazone tablet product was developed which produced a complete and more rapid absorption of the drug.
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