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  • Title: [Role of radionuclide imaging of bone marrow and spleen in choice of therapy and topometric preparation for radiotherapy of patients with Hodgkin disease].
    Author: Kanaev SV, Novikov SN, Gershanovich ML, Zhukova LA, Korobova IA.
    Journal: Vopr Onkol; 2002; 48(2):193-5. PubMed ID: 12227067.
    Abstract:
    Use of radionuclide methods of bone marrow (BM) and spleen visualization was assessed in 176 patients with primary Hodgkin's disease and 116 relapsing cases. The study was intended to help design treatment modality and carry out topometric measurements for exposure to radiation. Stage of tumor was revised in 19 primary patients as a result of BM scintigraphy, and this factor was responsible for major changes in the treatment modality in 11 patients (6.2%). This factor played a similar role in designing irradiation field boundaries in another 18 primary patients (10.2%). Similarly, the choice of treatment modality was revised in 33 relapsing patients (27.5%). The standard roentgenometric data on the anatomical reference points of the spleen and those of radionuclide-assisted visualization were compared in 37 patients. In 17 (45.9%), part of the spleen was shown by scintigraphy to be outside the irradiation boundaries delineated by the roentgenometric procedure. Roentgenometry located the spleen well inside the irradiation fields in 8 patients (21.6%). However, due to scintigraphy, their boundaries were altered to cut down the exposure of the left kidney (5) or the left lung (3). Complete agreement between roentgenometric and scintigraphic measurements were reported in 12 patients (32.4%) only.
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