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  • Title: Immunogenetics of the Lennox-Gastaut syndrome: frequency of HL-A antigens and haplotypes in patients and first-degree relatives.
    Author: Smeraldi E, Scorza Smeraldi R, Cazzullo CL, Guareschi Cazzullo A, Fabio G, Canger R.
    Journal: Epilepsia; 1975 Dec; 16(5):699-703. PubMed ID: 1222746.
    Abstract:
    Twenty-two patients with the Lennox-Gastaut syndrome and their families were examined for HL-A antigens by the microlymphocytotoxicity test. The antigen HL-A7 belonging to the HL-A locus showed a significantly increased frequency (p less than 0.0005) both in parents and in patients. The same antigen showed a significantly altered segregation in patients but a normal one in healthy siblings. Another antigen of the second HL-A locus, HL-A12, did not display a normal segregation in our patients, in whom it was nearly not represented.
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