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  • Title: Development and in vitro validation of a device for measuring non-shunt cardiac output by nitrous oxide throughflow.
    Author: Vartuli GM, Burfoot RB, Robinson GJ, Peyton PJ, Junor PA.
    Journal: Med Biol Eng Comput; 2002 Jul; 40(4):415-22. PubMed ID: 12227628.
    Abstract:
    A system has been developed for measuring non-shunt cardiac output by the throughflow technique, using nitrous oxide in patients undergoing general anaesthesia. The throughflow measurement technique is a non-invasive method based on inert gas throughflow theory. In vitro validation of the measurement system was performed using a lung gas exchange simulator. The accuracy and precision of the throughflow measurement system was assessed by comparing measured and target values for five simulated values of non-shunt cardiac output, from 2.88 to 9.86 l min(-1). This showed an overall mean bias of -0.031 min(-1) (range -0.00 to -0.101 min(-1)), with a mean coefficient of variation of the difference of 1.39% (1.20-1.93%). These results indicate that the measurement system is suitable for monitoring the non-shunt cardiac output in patients undergoing general anaesthesia using nitrous oxide throughflow.
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