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  • Title: Immunologic control of reproduction in dogs.
    Author: Pineda MH, Faulkner LC.
    Journal: Canine Pract; ; 1(2):11. PubMed ID: 12229455.
    Abstract:
    The immunologic control of fertility was studied in male dogs. Immu nization with ovine gonadotropin produced severe testicular and accessory gland atrophy. Immunization with purified bovine luteinizing hormone (LH) had similar effects on a short-term basis. In long-term experiments, there were degenerative changes in the germinal epithelium of the seminiferous tubules. Antibody serum titers correlated negatively with androgen levels. 5 weeks after immunization, ejaculation was inhibited, though some recovery was observed later. There were no undesirable side effects. Immunization with human chorionic gonadotropin did not appreciably alter reproductive function. Ejaculation was inhibited for at least 140 days after immunization with ovine pituitary gonadotropin. After recovery, ejaculation was again inhibited by a booster injection. Testicular diameter was markedly reduced by treatment. Clinical side effects were not evident.
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