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  • Title: Chinese medicine induces neurite outgrowth in PC12 mutant cells incapable of differentiation.
    Author: Kano Y, Takaguchi S, Nohno T, Hiragami F, Kawamura K, Iwama MK, Miyamoto K, Takehara M.
    Journal: Am J Chin Med; 2002; 30(2-3):287-95. PubMed ID: 12230017.
    Abstract:
    During continuous culture of neural PC12 cells, we obtained a drug-hypersensitive PC12 mutant cell that showed high stimulation of neurite outgrowth by various drugs. When several Chinese medicines such as shu-jing-huo-xie-tang and Wu-Ling-San were provided to these PC12 mutant cells, the frequency of nerve growth factor (NGF)-induced neurite outgrowth increased approximately 30-fold compared to NGF alone. Neurite outgrowth induced by NGF in PC12 cells is accompanied by sustained activation of mitogen-activated protein kinase (MAPK); however, these Chinese medicines did not induce MAPK activity. The findings thus indicate that certain Chinese medicines may induce neurite outgrowth by a novel mechanism which is distinct from the NGF-activated pathway in PC12 mutant cells.
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