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Title: Pharmacological evaluation of Shokyo and Kankyo (1). Author: Hashimoto K, Kase Y, Murata P, Kido T, Nakai Y, Sakakibara I, Higuchi M, Sasaki H, Okada M. Journal: Biol Pharm Bull; 2002 Sep; 25(9):1183-7. PubMed ID: 12230114. Abstract: Zingiberis Rhizoma (Shokyo, [Japanese characters: see text]) showed significant ameliorative effect on the BaCl2-induced delay of gastric emptying in rat. Bioassay-guided fractionation of the aqueous extract of Shokyo resulted in isolation of 6-gingesulfonic acid (1) and shogasulfonic acid A (3). These compounds significantly improved the delay of gastric emptying on both BaCl2-induced and N(G)-nitro-L-arginine (L-NNA)-induced model in rat. Zingiberis Siccatum Rhizoma (Kankyo, [Japanese characters: see text]) had significant efficacy against castor oil-induced diarrhea. In addition, Kankyo showed the activity increasing intestinal blood flow in normal rat.[Abstract] [Full Text] [Related] [New Search]