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  • Title: Saline cathartics and adsorptive capacity of activated charcoal for doxycycline.
    Author: Afonne OJ, Orisakwe OE, Ofuefule SI, Tsalha S, Obi E, Ilondu NA, Okorie O.
    Journal: Acta Pol Pharm; 2002; 59(3):177-9. PubMed ID: 12230243.
    Abstract:
    The effects of sodium chloride and sodium citrate on the in vitro adsorption of doxycycline to activated charcoal have been studied. Solutions of doxycycline alone and doxycycline with 7.5 mg/ml cathartic solutions were vortex-mixed for 30 s with different quantities of activated charcoal, incubated for 30 min at 37 degrees C and analyzed for free doxycycline spectrophotometrically at 348 nm. Addition of NaCl had a significant (p<0.05) increase while sodium citrate produced a significant (p<0.05) decrease in the adsorption of doxycycline on activated charcoal. In all, the adsorption doxycycline on activated charcoal obeyed quantity-dependent kinetics.
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