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  • Title: [Certain characteristics of myocardial metabolism in long-term experimental hypotension and the effect of administration of adenosine triphosphate and fructose 1,6-diphosphate].
    Author: Vilenskii IT.
    Journal: Kardiologiia; 1975 Dec; 15(12):69-73. PubMed ID: 1223363.
    Abstract:
    Several indices of energy exchange and protein-amino acid metabolism in the myocardium were studied experimentally in dogs subjected to long-term hypotension (Wiggers' technique, arterial pressure of 40 mm Hg for 3 hours). It was established that by the end of the fixed period of hypotension the myocardial content of adenosine triphosphate, creatinephosphate, glycogen decreased significantly, while the amount of nonorganic phosphorus, lactic and pyruvic acids increased. At the same time the content of watersoluble protein fraction and of most of the 18 identified amino asids decreases in the cardiac muscle. Fractionated intravenous injections of adenosine triphosphate or 1,6-diphosphate fructose permitted to prevent the development of energy deficit, and, to a great extent, that of protein-amino acid metabolism disorders in dogs subjected to long-term hypotension.
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