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  • Title: Lack of toxicity from concomitant directly observed disulfiram and isoniazid-containing therapy for active tuberculosis.
    Author: Burman WJ, Terra M, Breese P, Cohn D, Reves R.
    Journal: Int J Tuberc Lung Dis; 2002 Sep; 6(9):839-42. PubMed ID: 12234141.
    Abstract:
    We retrospectively evaluated the use of disulfiram among alcoholic patients being treated for active tuberculosis. There were 13 alcoholics treated with disulfiram, 105 alcoholics not on disulfiram, and 249 non-alcoholics. Rates of toxicity were higher among alcoholics than among non-alcoholics (58% vs. 32%), but there was no difference between alcoholics taking and those not taking disulfiram (61% vs. 57%). There were no neurological side effects in the disulfiram group. Disulfiram appeared to be safe when added to intermittent, directly observed isoniazid-containing tuberculosis treatment, and was useful in managing complications of alcohol abuse. However, the small number of patients on disulfiram limits the strength of this negative finding.
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