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  • Title: [Participation of the GABA B receptors in presynaptic inhibition of the spinal cord descending projections fibers in the frog Rana ridibunda].
    Author: Ovsepian SV, Veselkin NP.
    Journal: Ross Fiziol Zh Im I M Sechenova; 2002 Jul; 88(7):817-28. PubMed ID: 12238349.
    Abstract:
    (-)-Baclophen was found to depress in a dose-dependent and reversible way the excitatory post-synaptic potentials (EPSPS) of motor neurons and the ventral root potentials evoked by stimulation of fibres of the ipsi- and contralateral ventral columns. The (-)-baclophen depressing effect could be eliminated with saclophen. Picrotoxin eliminated the depressing effect of the GABA on the descending EPSPS. Depressing effects of (-)-baclophen and GABA upon the ventral root potentials were also shown. The data obtained in pharmacological analysis corroborate to a certain extent existence of the GABAB receptor presynaptic inhibition in descending fibres monosynaptically corrected with the spinal cord motor neurons in the frog Rana ridibunda.
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