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  • Title: Benzathine penicillin G and procaine penicillin G in piglets: comparison of intramuscular and subcutaneous injection.
    Author: Ranheim B, Ween H, Egeli AK, Hormazabal V, Yndestad M, Søli NE.
    Journal: Vet Res Commun; 2002 Aug; 26(6):459-65. PubMed ID: 12241099.
    Abstract:
    The disposition of penicillin G in piglets is described after intramuscular or subcutaneous injection of depot preparations. The piglets were injected with 33,000 IU/kg or 100,000 IU/kg benzathine + procaine penicillin G intramuscularly or subcutaneously, or 100,000 IU/kg procaine penicillin G intramuscularly or subcutaneously. Intramuscular injection of benzathine + procaine penicillin resulted in higher maximum concentrations in plasma (Cmax) than did subcutaneous injection. The mean residence time (MRT) of penicillin G was longer when the drugs were injected subcutaneously rather than intramuscularly. The plasma concentration versus time profiles of the subcutaneous injections of benzathine + procaine penicillin revealed secondary peaks, possibly reflecting a certain degree of inflammation at the injection site.
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