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  • Title: A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory.
    Author: Bourgeois C, Rocha B, Tanchot C.
    Journal: Science; 2002 Sep 20; 297(5589):2060-3. PubMed ID: 12242444.
    Abstract:
    The delivery of CD4 help to CD8+ T cell responses requires interactions between CD40 and CD40 ligand and is thought to occur through antigen-presenting cell (APC) activation. Here we show that generation of memory CD8+ T cells displaying an enhanced capacity for cell division and cytokine secretion required CD4 help but not CD40 expression by the APCs. Activated CD4+ and CD8+ T cells expressed CD40; and in the absence of this protein, CD8+ T cells were unable to differentiate into memory cells or receive CD4 help. These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation.
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