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  • Title: Isotretinoin-induced nail fragility and onycholysis.
    Author: Onder M, Oztaş MO, Oztaş P.
    Journal: J Dermatolog Treat; 2001 Jun; 12(2):115-6. PubMed ID: 12243670.
    Abstract:
    A 23 year old woman who presented with severe acne had been treated with 40 mg/day isotretinoin. On her monthly control, severe cheilitis and bilateral toe nail onycholysis were observed. It is well known that systemic retinoids have several side effects. Although dystropic nail, paronichia-like changes, median nail dystrophy have previously been reported with isotretinoin therapy, onycholysis is rare. In this report, we describe a case with isotretinoin induced nail fragility and onycholysis.
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