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  • Title: [Insulin hypoglycemia, a functional test of the state of the hypothalamo-hypophyseo-adrenal system in obesity].
    Author: Dobrev D, Pavlov D, Stoilov L.
    Journal: Vutr Boles; 1975; 14(5):73-8. PubMed ID: 1224611.
    Abstract:
    By provoking insulin hypoglycemia (activating the hypothalamus action) and by following-up of the subsequent cortisole response in plasma, the authors study the functional state of the hypothalamic-hypophyseal-suprarenal system in 18 patients with obesity, fourteen of them with regulative type, three -- with metabolic and one -- with hypogonadial type. The cortisole response proved to be within the normal limits in the patients with metabolic and hypogonadial obesity type. the insulin test shows pathological deviations in six, out of all 14 patients with regulative type of obesity. In those cases the cortisole response is low, its curve is with a plateau-like progress and represents a reliable index for a lesion in the hypothalamic-hypophyseal region. The normal test does not speak against the existence of similar lesions. In the presentce of other clinical and paraclinical data for hypothalamic-hypophyseal damage, the normal hypoglycemic test shows that the functional link between hypothalamus-hypophysis-suprarenals is still preserved and in that sence it also aids the determination of the lesion degree and is of diagnostic value. Based on their experience, the authors recommend a wider application in the clinical practice of insulin-hypoglycemic test.
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