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  • Title: [Spontaneous and induced variability in Actinomyces rubiginosohelvolus, a new producer of the antibiotic rubomycin].
    Author: Lapchinskaia OA, Saburova TP, Siniagina OP, Konstantinova NV, Filicheva VA.
    Journal: Antibiotiki; 1975; 20(12):1061-5. PubMed ID: 1225178.
    Abstract:
    Mutants possessing 3 times higher activity as compared to the initial culture were obtained as a result of selection of active variants of Act. rubiginosonelvolus, a new organism producing rubomycin against the background of variation induced by N-methyl-N1-nitro-N-nitrozoguinidine, diethylsulphate and their combinations. Further selection among the mutants stable to 6-mercaptopurine and riboflavine resulted in obtaining an active culture No. 3912 at least 7 times more active with respect to rubomycin production than the initial soil culture.
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