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  • Title: In vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin.
    Author: Wise R, Andrews JM, Bedford KA.
    Journal: Antimicrob Agents Chemother; 1978 Mar; 13(3):389-93. PubMed ID: 122520.
    Abstract:
    The activity of clavulanic acid alone and in combination with penicillin, amoxycillin, and carbenicillin was studied. Marked reductions in the minimum inhibitory concentrations (MICs) for a wide spectrum of beta-lactamase-producing clinical isolates were found. Of particular interest were the decreased MICs of penicillin for Bacteroides fragilis and beta-lactamase-producing strains of Neisseria gonorrhoea in the presence of the clavulanic acid. Beta-lactamase-producing strains of Escherichia coli, Klebsiella spp., and indole-negative Proteus also showed considerably increased susceptibility to amoxycillin in combination with clavulanic acid. Two beta-lactamase-producing strains of Pseudomonas aeruginosa remained resistant to carbenicillin in the presence of clavulanic acid.
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