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  • Title: Oral contraception and venous thrombosis.
    Author: Tyler ET.
    Journal: JAMA; 1963 Jul 13; 185(2):131-2. PubMed ID: 12255487.
    Abstract:
    Between 1961 and 1963 there were 347 instances of thrombophlebitis in women using a norethynodrel-estrogen combination (Enovid) for contraception reported to the manufacturer. Fatal pulmonary embolism occurred in 35 cases, of which 9 were due to causes other than Enovid. There is a serious lack of reliable statistics concerning the occurrence of thrombophlebitis or pulmonary embolism in the female population at various ages. A meeting of specialists in 1962 concluded that no evidence was available to relate spontaneous intravascular clotting with the use of oral contraceptives. Supporters of a simple contraceptive maintain that if Enovid is responsible for the problems noted, the incidence is extremely low and would probably be consistent with the rare-drug idiosyncrasy or sensitivity. There would be a greater health risk to those women who, through nonuse of any contraceptives (when they would have used the oral method), become pregnant and develop thromboembolism as a consequence of pregnancy.
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