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  • Title: Effects of age and genotype on acquisition of an active avoidance response in mice.
    Author: Stavnes K, Sprott RL.
    Journal: Dev Psychobiol; 1975 Sep; 8(5):437-45. PubMed ID: 1225707.
    Abstract:
    Two experiments were conducted in which inbred C57BL/6J and DBA/2J mice were trained in an active avoidance jump-up task under distributed practice conditions at a variety of ages comprising a large part of their life-span. DBA/2J mice were found to be basically an escaping strain and exhibited little change in behavior as a function of age. C57BL/6J mice developed consistent avoidance behavior when training was initiated at 31-36 days of age. Avoidance behavior appeared to reach a peak in the 45-day-old group and progressively decreased in 145- and 560-day-old groups. Increased footshock intensity in old DBA/2J mice enhanced escape responding without increasing avoidance responding. Increased footshock intensity in old C57BL/6J mice enhanced avoidance responding.
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