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  • Title: Induction of esophageal cancer associated with gastric cancer in a dog by N-ethyl-N'-nitro-N-nitrosoguandine.
    Author: Sekizuka H, Doi H, Sunagawa M, Nagai S, Kojima S.
    Journal: Gan; 1975 Dec; 66(6):683-8. PubMed ID: 1225722.
    Abstract:
    The experimental induction of gastric cancer was studied in four dogs given oral administration of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) in solution. Esophageal cancer with the regional lymph node metastasis was found in one dog at autopsy, with concomitantly existing gastric cancer. This dog, which ingested a total amount of about 38 g of ENNG, died of weakness on the 513th experimental day. Three remaining dogs are still living and under observation.
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