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  • Title: Endocrinology of human pregnancy.
    Journal: Res Reprod; 1975 Mar; 7(2):1. PubMed ID: 12258375.
    Abstract:
    3 studies on the endocrinology of human pregnancy are briefly reviewed. The 1st was a study on the changing patterns in levels of estrogen throughout pregnancy and the others considered the effects of prolactin and lactation on the endocrine events leading to a resumption of the menstrual cycle. Weeks 0-18 reflected the sequential activity of 3 sources of estrogen: the corpus luteum followed by the placenta and then the fetal adrenals. Between 18-30 weeks an equilibrium was estabilished with the levels of the 3 estrogens (estradiol-17beta, estriol, and estrone) fluctuating together. After 30 weeks the activity of the fetal adrenals reflected increasing amounts of estriol. Prolactin concentrations were found to be high during late pregnancy and early postpartum. Estrogen and luteinizing hormone (LH) remained low for about 28 days after birth. Follicle stimulating hormone levels were found to be low during late pregnancy and the 1st week postpartum but increased to normal whether or not suckling occurred. It is concluded that high levels of prolactin during lactation depress the secretion of estradiol-17beta and LH.
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