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  • Title: [Mechanisms of action of IUDs, with special reference to Cu-T devices].
    Author: Osa Gonzalez EL, Escudero Fernandez M.
    Journal: Acta Ginecol (Madr); 1975 Mar; 26():267-72. PubMed ID: 12258778.
    Abstract:
    On the basis of available data, the most likely action of IUDs is that of an endometrial polymorphonuclear infiltration, affecting both the upward movement of spermatozoa and the series of steps that precede implantation, although other actions may play a subsidiary role to a greater or lesser extent. With respect to IUDs of the Cu-T type, it appears that basically they act through metabolic endometrial changes initiated by actions affecting enzyme systems, which prevent the endometrium from becoming receptive to nidation. It is also highly probable that they have a harmful effect on the spermatozoa moving through the uterine cavity, and it is possible that cervical mucus, under the action of Cu-T IUDs, may alter its function as sperm filter, rendering sperm penetration more difficult, although the latter action is still being researched. Blastocysts appear to remain unaffected by all the actions of Cu-T IUDs.
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