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  • Title: The use of Depo-Provera in East London.
    Author: Savage W.
    Journal: Fertil Contracept; 1978 Jul; 2(3):41-7. PubMed ID: 12260723.
    Abstract:
    In London, a study was conducted on the use of Depo-Provera (medroxyprogesterone acetate) for short-term contraception, and although it was approved by the Committee on Safety of Medicines, long-lasting progestogen injections for contraceptives has not been. Only two specific groups of women, those whose husbnads were to undergo a vasectomy and those who have been immunized against rubella for the active period of the virus, were allowed to use Depo-Provera. A follow-up of 184 women given Depo-Provera showed 13 had iatrogenic problems; 4 had dilatation and currettage for irregular bleeding, 4 were referred to outpatients because of amenorrhoea, and 5 were referred because of irregular bleeding. Many women have reported mood changes, breast discomfort, loss of libido and vaginal dryness as well as menstrual disturbances and weight gain. From the incidence of iatrogenic problems and from discussions with follow-up patients, only 20% were properly informed of the effects of the method. Depo-Provera is a powerful steroid which disturbs the metabolism to a greater extent than oral contraceptives with the added disadvantage of it lasting 3 to 9 months after a single injection. Because the prescription of Depo-Provera was rising by doctors who may never see the woman again, the effect of licensing Depo-Provera as a long-term contraceptive would be hazardous for women unless its use was strictly controlled.
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