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  • Title: Sensibility of pituitary, gonadal and thyroid function in adolescence without and after hormonal contraception.
    Author: Rey-stocker I, Zufferey MM, Lemarchand Mth, Rais M.
    Journal: Contracept Fertil Sex (Paris); 1979 Jun; 7(6):419-40. PubMed ID: 12261224.
    Abstract:
    The maturation of the hypothalamo-hypophyso-ovarian system comes about gradually, through an increase of the sensibility of the hypophysis to the action of estrogens. To measure this sensibility 76 adolescents aged 2-5 years after menarche were administered continuous hormonal contraception during a period of 3-24 months. Between the 21st and the 25th day of the cycle after contraception had been stopped, all basal values of gonadotropins, thyrodropins, prolactin, and their responses to injections of 50 mg. of luteinizing hormone-releasing hormone, and of 200 mg. of thyrodropin-releasing hormone were measured. Results were compared to those of another group of adolescents who had had no treatment, and to a group of young nulliparous women with ovulatory cycles, and who had had no treatment. Results showed that between menarche and adult age there is a significative rise in basal level of estradiol and of luteinizing hormone; progesterone secretion also increases. However, even 6 years after menarche basal levels are very far from being similar to those of adult women. Prolactin level also augments, varying according to menstrual cycle phase and according to age. Oral contraceptives do not seem to inhibit the regular functions of the hypothalamo-hypophyso-ovarian system if taken at this early age.
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