These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Uterine response to PGE2 with IUDs: a possible mechanism of action and side effect.
    Author: Toppozada M, Rizk M, Thabet MH, Shaala S.
    Journal: Contracept Deliv Syst; 1980 Oct; 1(4):349-63. PubMed ID: 12262137.
    Abstract:
    10 healthy nonpregnant women aged 20 to 35 years with at least 2 children and normal regular menstrual cycles participated in this study which was conducted to determine the effects of IUDs on uterine activity and to study uterine response to PGE2 (prostaglandin E2) before and after IUD insertion. The women were recruited on days 2 to 3 of the cycle. Uterine activity was recorded in 3 sessions (proliferative phase; midcycle; secretory phase) during the control cycle. Spontaneous contractility patterns were recorded in all cases followed by local PGE2 administration in 7 cases. A plain Lippes Loop size C was inserted in the next cycle and uterine contractility recorded during the same phases and on same days following same experimental design as control cycle. The results show that Lippes loop size C causes an increase in spontaneous contractility of the nonpregnant uterus, depending on phase of the cycle studied. Changes were minimal in the proliferative phase (3 out 7 cases) and more common in the other phases (all cases in luteal and menstrual phases). Excessive or irregular bleeding and cramps may be traced to the general tendency towards hypermotility due to the presence of IUDs. The contraceptive action of IUDs may be partly attributed to the uterine hyperactivity observed in the early or mid-luteal phase after IUD insertion. Increased uterine sensitivity to local instillation of PGE2 at the proliferative and luteal phases was observed following IUD insertion. Post-insertional changes in basal motility was also attributed in part to the increased or altered uterine reactivity to PGs as a result of IUD insertion.
    [Abstract] [Full Text] [Related] [New Search]