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  • Title: Prostaglandins (PGS).
    Author: Sammour M.
    Journal: Ain Shams Med J; 1971 Sep; 22(5):551-2. PubMed ID: 12263794.
    Abstract:
    A brief summary presents a history of scientific knowledge concerning PGs (prostaglandins). Referring to the results of selected clinical studies, current knowledge regarding the biologic effects of PGs is discussed. There seems to be a correlation between oligospermia and PG concentrations in the semen. PGs cause either relaxation or contraction of the nonpregnant myometrium, varying according to the time of the menstrual cycle. The antifertility properties of PGs may result from their delaying effect on ovum transport. PGs have been identified in amniotic fluid during spontaneous abortion and labor and in venous blood during normal labor and abortion. The most important current clinical use for PGs is in abortion induction. The problem is in using a dosage large enough to cause the abortion but small enough to minimize side effects. Monthly administration of PGs may serve as a contraceptive, working either through delay of ovum transport, an effect on the implantation site, as an abortifacient, or by luteolytic effects.
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