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  • Title: [Analysis of radioreceptors of human chorionic gonadotropins: a new tool for the diagnosis and management of pregnancy].
    Author: Saxena BB, Ladesman R.
    Journal: Estud Poblac; 1979; 4(7-11):13-29. PubMed ID: 12264282.
    Abstract:
    For the past 50 years the diagnosis of early pregnancy has been based on the detection of human chorionic gonadotropin (HCG). The introduction of the analysis of the radioreceptor (ARR) of HCG, discovered by Saxena in 1974, has recently led to the greatest improvement in pregnancy tests. Since only the radioreceptor can recognize the original form of the hormone, the ARR combines the specificity of bioanalysis with the sensitivity of radioimmunoassay. The qualtitative ARR of HCG has a sensitivity of 6mIU/ml, and it is about 500 times more sensitive than the test of agglutination of hematin or of latex; the qualitative, positive or negative, ARR of HCG has a sensitivity of about 200mIU/ml, or 6 times greater than the test of agglutination of hematin or latex. The ARR of HCG can detect pregnancy 1 week after ovulation; it can also detect twin pregnancies, and trophoblastic diseases or ectopic tumors, thus allowing abortion to be performed before 6 weeks of pregnancy. The high effectiveness of ARR has been demonstrated in more than 100,000 pregnancy tests conducted at the Cornell Medical College.
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