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  • Title: Thyroid function tests under the effect of steroidal contraceptives compared to normal pregnancy.
    Author: Nasr EM, El-mekkawi T, Abbas A, El-sheikha Z, Abdel Aziz A.
    Journal: Popul Sci; 1982; (3):157-68. PubMed ID: 12266214.
    Abstract:
    The effects of the oral contraceptive pill on th blood and urinary levels of various hormones was studies using 5 groups of women. Group 1 consisted of 59 women using combined contraceptive pills for 1 to 12 years under the commercial names of primovlar (25 cases) Anovlar (19 cases) and Ovral (15) cases; group 2 consisted of 50 pregnant women during the 1st trimester; group 3 consisted of 50 pregnant women during th 2nd trimester; group 4 consisted of 50 pregnant women during the 3rd trimester and group 5 was the control group consisting of 10 fertile nonpregnant women. Triiodothynine (T3) and throxine (T4) were determined in the sera of 59 women using combined contraceptive pills (estrogen 0.05 mg and progestogen 0.5 mg/pill), 150 pregnant women during the 1st, 2nd and 3rd trimesters and 10 normal fertile women used as controls. There were marked differences in the value of thyroid function tests in the euthyroid nonpregnant and euthyroid pregnant women. The effect of contraceptive pills coincided with the effect of pregnancy during the 3rd trimester. The protein bound iodine (PBI) shows insignificant increase during the 1st and 2nd trimester, while significant increase has been found during the 3rd trimester and in contraceptive pill users, p0.05. Total serum thyroxine shows insignificant increase occurred during the 3rd trimester and in contraceptive pill users. Thyro-binding Index showed no change than normal control during the first, second and third trimesters, while a nonsignificant increase has been found in contraceptive pill users, p0.05% uptake of T3 is not changed during the 1st and 2nd trimesters, while a decrease has been noticed in contraceptive pill users (21.8%) and a slight decrease occurred during 3rd trimester(27.9%) compared to the normal nonpregnant group
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