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  • Title: [Comparative study of the intensity of production of LPV oncornavirus by T-9 cell line and an infected culture of human diploid cells].
    Author: Andzhaparidze OG, Lotte VD, Stepanova LG, Andzhaparidze AG.
    Journal: Vopr Virusol; 1975; (6):655-9. PubMed ID: 1226702.
    Abstract:
    A culture of transformed cells, T-9 line, producing LPV oncornavirus and a culture of human diploid cells (HDC) infected with a cell-free ultrafiltrate of these transformed cells were examined in the electron microscope. The study was aimed at determination of the optimal time and intensity of LPV oncornavirus production by one cell of transformed and infected cultures. LPV oncornavirus production in T-9 cell culture was found to have a pattern of slowly developing, non-intensive two-wave process, whereas in infected HDC culture the process was progressing actively resulting in an increase of the amount of intracytoplasmic type A particles and extracellular type B and C virions by 10- and 15-fold, respectively, within 48- 96 hours for T-9 culture and 96 hours for infected HDC. Cell transformation was found to be apparently preceeded by the infectious process the intensity of which decreased as fibroblast cell culture was transformed into a culture of epithelioid cells.
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