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  • Title: Copper-7 IUD: clinicians, data support four years of use.
    Journal: Contracept Technol Update; 1985 Sep; 6(9):121-4. PubMed ID: 12267197.
    Abstract:
    In a survey of physicians across the US, 11 of 16 of them already find 4 or more years of Copper-7 use acceptable. In addition, the Copper-7 developer, Jaime Zipper, M.D., reported as early as 1976 that the contraceptive effectiveness of the Copper-7 is not modified in the 4th year. Irvin Strathman, M.D., Searle's director of medical affairs, says that the company currently has no plans to ask the Food and Drug Administration (FDA) to revise its recommendation that the Copper-7 may be used for 3 successive years. He said that the studies that led to Copper-7 approval had data which supported use for 3 years. Studies which led to the IUD's approval have been terminated, and no additional data were developed. Study results regarding the Copper-T 200 prompted the Population Council to ask for an extension for the device. At the heart of the Copper-7 issue is whether or not the device is effective during the 4th year of use and beyond. Study results indicate that the Copper-7 and the Copper-T remain highly effective after 4 years of use. Findings published from 1976-81 that emphasize prolonged effectiveness of the Copper-7 and Copper-T include the following: in 4 successive years of observation, net annual pregnancy rates of 2.3, 1.8, 2.1, and 0.9 were reported by Zipper et al.; in a separate study by Zipper et al., it was found that the annual pregnancy rates did not increase with increasing use duration; in an evaluation of 278 women who used Copper-7 IUDs for 4 successive years, Larsson et al. reported a net cumulative pregnancy rate of 3.6 after the 4th year; the cumulative pregnancy rate for 5 successive years of Copper-T 200 use was 4.84% in a study at the Hospital of the China Welfare Institute; and in a study conducted at the New York Medical College-Metropolitan Hospital Center, the authors concluded that Copper-7 users who did not return for their IUD removals after 3 years, but were followed up at a later date, seemed to have no problems and to be well protected from pregnancy after 4 and 5 years of continuous usage. In his response to the survey about IUDs, Dr. George Denniston, president of Population Dynamics, Seattle, said he had found 4 years of Copper-7 use acceptable for his patients for 10 years. According to a report on IUDs by the Population Information Program at Johns Hopkins University, other data support extended use of copperbearing IUDs. The report cited a study that found between 50-70% of the copper on the T-200 and Copper-7 remained intact after 4-5 years of use.
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