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  • Title: Future prospects in male contraception.
    Journal: Netw Res Triangle Park N C; 1987; 8(4):8. PubMed ID: 12269106.
    Abstract:
    Biologically, it is simpler to control women's fertility than men's yet methods to control male fertility are of interest to researchers. The regular use of gossypol was found to have sperm-suppressing effects in China and was carefully studied by researchers in the 1970s, but as it causes potassium deficiency and reduced libido in some men it is unlikely to come into widespread use. Injections and nasal sprays of luteinizing hormone-releasing hormone analogues and injectable androgen-progestin combinations have received considerable study, but they are not expected to provide family planners with new methods for a long time. Consequently, much current study focuses on ways to improve existing male methods -- vasectomy and the condom -- and to make them both more convenient and appealing to potential users. Puncture techniques developed in China and England may achieve this for vasectomy. These methods puncture the vasa percutaneously and inject them either with a chemical coagulating agent (China) or seal them by electrocoagulation (England). The advantage of puncture techniques is that they avoid incision and bleeding, allowing faster healing with less discomfort than standard incision techniques. Disadvantages include that these procedures may be more difficult to perform, more difficult to reverse, and have slightly higher failure rates than surgical vasectomy. Another way to attract more men to vasectomy is to improve the chances for reversal. The "shug" method is 1 method that would allow easier reversal. This procedure inserts by needle 2 silicone plugs in each vas to block sperm passage. The plugs are connected by a nylon thread which remains outside the vas and which is used to pull out the plugs in reversal. In response to Acquired Immune Deficiency Syndrome (AIDS), technical improvements in condoms to maintain or enhance sensitivity during sexual activity and to minimize breakage and leakage are a new priority among researchers. Condoms lubricated with the spermicide nonoxynol-9 represent 1 area of study in AIDS research. In the laboratory, nonoxynol-9 has been found to kill the AIDS virus.
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