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  • Title: Recurrence of allergic rhinitis, previously alleviated with allergen immunotherapy, after autologous bone marrow transplant.
    Author: Kelso JM.
    Journal: Ann Allergy Asthma Immunol; 2002 Sep; 89(3):316-8. PubMed ID: 12269654.
    Abstract:
    BACKGROUND: Several associations between immunoglobulin E and bone marrow transplantation (BMT) have been reported. OBJECTIVE: A patient whose allergic rhinitis (AR) resolved after allergen immunotherapy (AIT) but recurred after the patient received an autologous BMT is reported. METHODS: Allergy skin tests were performed before AIT began and after 4 years of therapy. Skin tests were repeated after a recurrence of symptoms 6 years later after an autologous BMT for breast cancer. RESULTS: Six years of AIT led to a near complete resolution of AR symptoms. Skin tests showed a marked reduction in reactivity to allergens in the AIT. After an additional 6-year symptom-free interval off AIT, symptoms returned after the BMT. Repeat skin tests showed a marked increase in reactivity. CONCLUSIONS: Patients reconstituting their immune systems after autologous BMT may have a recurrence of AR previously suppressed with AIT.
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